Monday, May 20, 2024

XX vs XY

 Annamaria on Monday


All of my siblings are XYs. I, on the other hand, am an XX. Having grown up with three brothers (one 16 months older than I, one 9 years younger, and the third 15 years younger), I have always had a perfect observation point from which to study the males of the species. I also had a wonderful dad, and a gaggle of sometimes nice, but sometimes pretty nasty uncles and mostly boy cousins. I think this is why I have always had easy friendships with boys and men.  I got used to them at an early age.

I am telling you all this because I am concerned that some readers may take what I have to say today as misandry. It is not. I do not look down upon, much less hate men.  Not at all! What I am reporting on today are scientific facts. 




But before I get into that, I do confess that I have been joking for many years about the comparison of people with XX chromosomes versus XY chromosomes.  Whenever women friends complain about the shortcomings of the males in their lives - husbands, boyfriends, bosses, etc. - it has been my habit to point out that we have two X chromosomes, and they have an X and a Y. I then postulated that the so called Y is really an X with a piece missing. Consequently, males of the species do not always react to the world around them with the wisdom of a woman.  Hahaha. I got a lot of laughs with that line.  All of them from women!




Then, I heard about the book The Better Half, subtitled On the Genetic Superiority of Women, by  Sharon Moalem, MD. PhD.  Dr. Moalem is a geneticist and in his book, he reveals in detail how that Y in men actually is, so to speak, an X with a piece missing.



He noticed, at the beginning of his medical career, that challenged baby girls were much more likely to survive their difficulty than boys who were similar in all other ways.

Eventually his research went deep into questions of why and how having a woman's immune system or having two X chromosomes give women an advantage.  As it happens, damanged chromosomes cause a lot of the problems that crop up in human lives.  In the book, Dr. Moalem uses the metaphor of a hybrid car.  "In some situations being gas powered is better; in others electric works better.  When the damaged gene causes a disease, a little girl's body can reach out to the spare and heal itself, where the boy child often has no such option.

A great deal of female superiority comes from having an immune system boosted by the stuff in that piece the guys are missing.  The longer life-expectancy of women, which is universal among humans, generally speaking keeps us healthier longer.


Throughtout most of human history, men were considered the stronger sex.  Perhaps this is because they are generally taller and have stronger muscles.  In times of famine however, the females' storage of protein in fat is much more efficient and helpful than those big muscles, which cannot keep their owner alive.

There is downside to the strength of the female immune system.  We XXs are much more likely to have auto immune diseases, such as lupus.  I myself have two, and a ton of allergies.  I blame my hyper-active immune system for all that.  But I also credit it with the overall state of my health.  

The doc's book explains all this science in an easy, conversational style.  I highly recommend it.

   

When it comes to XX vs XY, I still can say vive la difference! I can also say I have always been glad to be a girl. Thanks to Dr. Moalem, I can now  tell you why.



6 comments:

  1. I was going to make a flippant comment, but on second thoughts I can only get into trouble! But interesting that this links to the longevity issue, which is very well established. Ask any insurance company.

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    1. From AA: As long as we’re still friends…
      I actually thought about you when reading the book, Michael. In style and context, it is a lot like the one you recommended about the capabilities of all sorts of creatures. Fascinating in the the details and their effects.

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  2. I knew that men's lack of a second X made them vulnerable in many ways, but I didn't know about why women have more auto-immune illnesses. Fascinating and delightfully written, Annamaria. I really enjoyed this.

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    1. From AA: Thank you, Kim. I was not quite finished the book when I wrote this. The doc goes on the decry the insanity that drugs that will be prescribed for both men and women have often been tested only on men. And something I— who always get the side effects—have noticed. They prescribe the same dosage for men and women.
      The craziest news to me is that in preliminary testing, they have been using only male lab mice. Inexplicable!!

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  3. Thanks for this--I'm in the same position (only girl in my generation!) and yes--auto immune, allergy & epilepsy issues though I'd not realised why!

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    1. I am so sorry to hear that you suffer these issues, dear Ovidia.

      I love all the other things that we have in common, but not this!

      I recommend the book. Having read it, from now on, when a doctor recommends medication for me, I am going to ask if the chemical itself snd the dosage is particularly recommended for women. The chapter on testing, prescribing, and dosage levels, when it comes to women is positively infuriating in the way those actions generally ignore the genetic differences between men and women. Difficult to hear cBut very important for people like you and me to know.
      I hope that you can find relief, any way It can come to you. Up to you from me.

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